Allergic reactions, some which can be potentially severe, have been reported during the use of Synvisc-One. Synvisc-One is usually administered by a specialist trained in treating knee osteoarthritis, such as an orthopaedic surgeon or rheumatologist.īefore trying Synvisc-One, tell your doctor if you have had an allergic reaction, such as swelling of the face, tongue or throat, respiratory difficulty, rash, itching or hives to SYNVISC or any hyaluronan-based products. To watch a video of a real patient’s injection, click here. Synvisc-One is a single-dose treatment that is injected directly into your knee by a doctor. If you’ve tried these options and are still feeling knee pain, tell your doctor and ask if Synvisc-One is for people with knee osteoarthritis who have not received enough pain relief from diet, exercise and over-the-counter pain medication. How do I know if I’m ready for Synvisc-One? The body’s own hyaluronan acts like a lubricant and a shock absorber in the joint and is needed for the joint to work properly. Hyaluronan is a natural substance found in the body and is present in very high amounts in joints. The injection contains a gel-like mixture made from a substance called hyaluronan (pronounced hy-al-u-ROE-nan) that comes from chicken combs. Click the play button above to learn how Synvisc-One supplements your knee joint fluid to relieve the pain and improve your knee joint's natural shock absorbing abilities. In knees with osteoarthritis, the joint fluid (called synovial fluid) can break down and not provide the cushioning your knee needs.